Research

The definitive endoderm gives rise to the epithelium of the digestive tract, the respiratory system, and several endocrine and exocrine glands. Our experiments in mouse and chick embryos are designed to: (I) identify the signals that induce different organs at different positions in the digestive tract (II) determine the pancreas-specific transcription factors induced and how their network controls organogenesis and (III) determine how these signals lead to cancer or diabetes when inaccurately controlled.

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